[LMU-OSC News] Talk by Lisa McShane: "Reproducibility of omics research: Shared responsibility and consequences of ignorance"
LMU Open Science Center News
lmu-osc at lists.lrz.de
Wed Oct 17 08:45:42 CEST 2018
[News from our website:
https://www.osc.uni-muenchen.de/news/mcshane/index.html]
#Lisa McShane: "Reproducibility of omics research: Shared responsibility
and consequences of ignorance"
A talk by the Acting Associate Director, Division of Cancer Treatment
and Diagnosis, National Cancer Institute
The IBE, LMU Open Science Center, STRATOS, and the European Bioconductor
Meeting cordially invite to a guest talk:
**When: December 5, 2018 - 5 pm s.t.**
**Where: Schellingstr. 3, Room S005**
*Abstract:*
Irreproducible biomedical research is particularly concerning because
flawed findings have the potential to make their way to clinical studies
involving human participants. Many factors have been suggested as
contributors to irreproducible biomedical research, including poor study
design, analytic instability of measurement methods, sloppy data
handling, inappropriate and misleading statistical analysis methods,
improper reporting or interpretation of results, and on rare occasions,
outright scientific misconduct. Potential for these problems to occur is
amplified when the research involves use of novel measurement
technologies such as “omics assays” which generate large volumes of
data requiring specialized expertise and computational approaches for
proper management, analysis and interpretation
[http://www.nationalacademies.org/hmd/Reports/2012/Evolution-of-Translational-Omics.aspx].
Successful translation of omics research findings to safe and effective
clinical tests requires a research team with expertise including
laboratory and clinical science, bioinformatics, computational science,
and statistics. Team members share responsibility for ensuring that
research is performed with integrity and best practices are followed to
ensure reproducible results. Although making data and computer code
publicly available are valuable and important first steps toward
promoting reproducible research, they are not sufficient. Through a
series of case studies, the many dimensions of reproducible omics
research are explored, and shared responsibilities are discussed.
Maintaining a culture of reproducible research requires effort,
resources, and vigilance to counter many potential threats.
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