January 2020 - lmu-osc - lists.lrz.de

Some free places at the workshop: "Design of Replication Experiments" (Feb 6)
by LMU Open Science Center News Jan. 29, 2020

Jan. 29, 2020

[News from our website: https://www.osc.uni-muenchen.de/news/workshop_privacy11/index.html] We have a few free places for the: # Workshop: "Design of Replication Experiments" led by Leonhard Held, Charlotte Micheloud and Samuel Pawel (University of Zurich) Abstract: Statistical power is of central importance in assessing the reliability of science. Appropriate design of a replication study is key to tackling the replication crisis as many such studies are currently severely under-powered. The workshop will describe standard and more advanced methods to calculate the required sample size of a replication study taking into account the results of an original discovery study. Participants will learn how to use the R-package ReplicationSuccess. Prerequisites include basic R-knowledge and familiarity with concepts of statistical inference. *Trainer*: Leonhard Held is Professor of Biostatistics at the University of Zurich and Director of the Center for Reproducible Science. Charlotte Micheloud and Samuel Pawel are PhD students developing new methodology for the design and analysis of replication experiments. **When**: February 6th 2020, 8am-12pm **Where**: Richard-Wagner-Straße 10, Room D105, 80333 München **Interested to participate? Please sign-up** by sending an email to Prof. Ulrich Mansmann ulrich.mansmann(a)lmu.de --- This workshop comes as a "bundle" with a talk by Leonhard Held: > ##Upcoming talk "The harmonic mean chi-squared test to substantiate > scientific findings" > > by Prof. Dr. Leonhard Held, Professor of Biostatistics at the > University of Zurich and Director of the Center for Reproducible > Science > > **Abstract**: > > Statistical methodology plays a crucial role in drug regulation. > Decisions by the FDA or EMA are typically made based on multiple > primary studies testing the same medical product, where the two-trials > rule is the standard requirement, despite a number of shortcomings. A > new approach is proposed for this task based on the (weighted) > harmonic mean of the squared study-specific test statistics. > Appropriate scaling ensures that, for any number of studies, the null > distribution is a chi-squared distribution with one degree of freedom. > Further properties are discussed and a comparison with the two-trials > rule is made, as well as with alternative research synthesis methods. > An attractive feature of the new approach is that a claim of success > requires each study to be convincing on its own to a certain degree > depending on the significance level and the number of studies. A real > example with 5 clinical trials investigating the effect of Carvedilol > for the treatment of patients with moderate to severe heart failure > patients is used to illustrate the methodology. As a by-product, the > approach provides a calibration of the sceptical p-value recently > proposed for the analysis of replication studies. > > **Speaker**: > > Leonhard Held is Professor of Biostatistics at the University of > Zurich and Director of the Center for Reproducible Science. > > **When**: 5.2.2020 von 16:00 - 18:00 Uhr > **Where**: Luisenstrasse 37, Raum C006 --- ![](cid:97014F38-F122-4B2B-80B1-1E8A8BA531F1@psy.lmu.de "PastedImage.png") http://www.osc.lmu.de/ Follow us on Twitter: https://twitter.com/lmu_osc Join our email newsletter: https://lists.lrz.de/mailman/listinfo/lmu-osc [Unsubscribe](https://lists.lrz.de/mailman/listinfo/lmu-osc) from the newsletter.

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ReproducibiliTea Journal Club: 29.1., 12:30
by LMU Open Science Center News Jan. 20, 2020

Jan. 20, 2020

Hello all, we would like to invite you to the second meeting of the Journal Club "ReproJuicebiliTea". We will take a closer look at possible solutions to improve the reproducibility and robustness of research. **When?** Wednesday, 29.01. 12.30-14 s.t. **Where?** Leopoldstraße 13, room 1407 (Building 1, 4th floor) **Paper**: Munafò, M. R., Nosek, B. A., Bishop, D. V. M., Button, K. S., Chambers, C. D., Percie du Sert, N., Simonsohn, U., Wagenmakers, E.-J., Ware, J. J., & Ioannidis, J. P. A. (2017). A manifesto for reproducible science. Nature Human Behaviour, 1(1). https://doi.org/10.1038/s41562-016-0021 **Procedure**: Again, we will start with a short summary of the paper and then continue with the discussion in which you can contribute your own thoughts and questions. For your orientation you can use the following key questions. If you know that you are coming please let us know by sending a short email to stephan.nuding(a)yahoo.de. We look forward to see you there! **Key questions**: 1. How can the system be changed in the long term, so that reproducible research is promoted independently of the research results? 2. How can we promote continuous education among scientists of all ages? 3. What changes are central to the training of young scientists in order to promote sustainably robust and reproducible research? 4. What other problems could arise during and through the implementation of the measures described in the article? Your organisation team Laura Goetz, Stephan Nuding, Leonhard Schramm & Felix Schönbrodt --- ![](cid:4569A807-4467-4DCC-81B9-B04C1C8319B7@psy.lmu.de "PastedImage.png") http://www.osc.lmu.de/ Follow us on Twitter: https://twitter.com/lmu_osc Join our email newsletter: https://lists.lrz.de/mailman/listinfo/lmu-osc [Unsubscribe](https://lists.lrz.de/mailman/listinfo/lmu-osc) from the newsletter.

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OSC now has 50 individual members
by LMU Open Science Center News Jan. 13, 2020

Jan. 13, 2020

[News from our website: https://www.osc.uni-muenchen.de/news/newsmember3/index.html] # Welcome to the OSC: 5 new individual members The number of individual members of the OSC is continuously increasing since its foundation in November 2017 with 17 founding members. With our 5 new members, **the OSC counts 50 members from 15 different disciplines**. We are happy to introduce our new members, in alphabetical order: ### Prof. Dr. Peter Falkai ![](cid:0C346B10-FF80-429F-8C17-518A9E34738E@psy.lmu.de "falkai.jpg") I am the Medical Director of the University Hospital Munich. Performing basic scientific and clinical studies in the field of schizophrenia research for the last 30 years, I am very interested in replicable findings and an openness for the community to work with our data. We have just been able to publish our first paper open-science and hope many more to come. ### Prof. Dr. Eva Grill ![](cid:2D9280DE-7C5B-47A7-AF3A-3CF34F827357@psy.lmu.de "grill.jpg") I am professor for epidemiology, specifically interested in successful ageing and the vestibular system, at the Department of Medical Informatics, Biometry and Epidemiology. In my team we try to adopt principles of Open Science into our daily work, e.g. by commenting code, verifying code and results, and by increasing awareness among project partners, collaborators and students. ### Dr. Giovanni Picogna ![](cid:578F9880-AB0C-4204-8E27-542209D9CD41@psy.lmu.de "picogna_801.jpg") I am a postdoctoral researcher at the Observatory of the LMU, working on planet formation. During my career I have come to understand how essential is openness into the scientific process, and how much it can help it to spur. I work with numerical simulations to recreate observations, in order to understand the physical processes at the base of planet formation. Many details can be hidden under the carpet, both from the observational and numerical side. In my work I am trying to explain all the assumptions made during my work, and I am planning to render more public all the codes and data used during the simulations and in the post-processing phase. ### Dr. Matthias Reinhard ![](cid:D3994691-9D5E-4D06-912F-EC6AF2CC7C82@psy.lmu.de "reinhard.jpeg") I am medical doctor and clinical researcher at the Department of Psychiatry of the University Hospital Munich. ### Dr. Andreas Schneck ![](cid:0650748C-BFBA-4CDD-ACFB-4CAAA035828E@psy.lmu.de "schneck.jpg") I am postdoctoral researcher at the chair of Quantitative Methods of Social Research (Department of Sociology). Besides my interest in researching the causes and contextual factors of social inequality using also meta-analytical tools I do methodological research on detection methods of publication bias and the assessment of scientific integrity. I am convinced that norms of transparency, sharing data and analysis files as well as establishing good practices of replication, and further interventions of open science are important to advance the quality as well as increase the efficiency of science. Thank you for joining the initative! --- ![](cid:BD0CA9F8-D922-41C6-B91C-9431B4124B59@psy.lmu.de "PastedImage.png") http://www.osc.lmu.de/ Follow us on Twitter: https://twitter.com/lmu_osc Join our email newsletter: https://lists.lrz.de/mailman/listinfo/lmu-osc [Unsubscribe](https://lists.lrz.de/mailman/listinfo/lmu-osc) from the newsletter.

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